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1

Molecular etiology of gut malformations and diseases

Pascal De Santa Barbara, Gijs Robert Van Den Brink, Drucilla Jane Roberts

Journal:

American Journal of Medical Genetics Part A

Année:

2002

Langue:

english

Fichier:

PDF, 131 KB

english, 2002

2

Leptin Signaling in Human Peripheral Blood Mononuclear Cells, Activation of p38 and p42/44 Mitogen-Activated Protein (MAP) Kinase and p70 S6 Kinase

Gijs R. van den Brink, Tom O'Toole, James C.H. Hardwick, Daniëlle E.M. van den Boogaardt, Henri H. Versteeg, Sander J.H. van Deventer, Maikel P. Peppelenbosch

Journal:

Molecular Cell Biology Research Communications

Année:

2000

Langue:

english

Fichier:

PDF, 213 KB

english, 2000

3

A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein

VERSTEEG, Henri H., NIJHUIS, Evert, VAN DEN BRINK, Gijs R., EVERTZEN, Maaike, PYNAERT, Gwenda N., VAN DEVENTER, Sander J.H., COFFER, Paul J., PEPPELENBOSCH, Maikel P.

Journal:

Biochemical Journal

Année:

2000

Langue:

english

Fichier:

PDF, 262 KB

english, 2000

4

Study of calcium signaling in non-excitable cells

Van Den Brink, Gijs R., Bloemers, S. Margreet, Van Den Blink, Bernt, Tertoolen, Leon G.J., Van Deventer, Sander J.H., Peppelenbosch, Maikel P.

Journal:

Microscopy Research and Technique

Année:

1999

Langue:

english

Fichier:

PDF, 831 KB

english, 1999

5

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

Liudmila L. Kodach, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Daniel W. Hommes, Gijs R. van den Brink, Carel J. M. van Noesel, G. Johan A. Offerhaus, James C. H. Hardwick

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 273 KB

english, 2008

6

Quality of web-based information on inflammatory bowel diseases

Sander van der Marel, Marjolijn Duijvestein, James C. Hardwick, Gijs R. van den Brink, Roeland Veenendaal, Daniel W. Hommes, Herma H. Fidder

Journal:

Inflammatory Bowel Diseases

Année:

2009

Langue:

english

Fichier:

PDF, 160 KB

english, 2009

7

Neutralizing antibodies against adeno-associated viruses in inflammatory bowel disease patients: Implications for gene therapy

Sander van der Marel, Elisabeth M. Comijn, Hein W. Verspaget, Sander van Deventer, Gijs R. van den Brink, Harald Petry, Daniel W. Hommes, Valerie Ferreira

Journal:

Inflammatory Bowel Diseases

Année:

2011

Langue:

english

Fichier:

PDF, 344 KB

english, 2011

8

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

Anne Christine W. Vos, Manon E. Wildenberg, Ingrid Arijs, Marjolijn Duijvestein, Auke P. Verhaar, Gert de Hertogh, Séverine Vermeire, Paul Rutgeerts, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Inflammatory Bowel Diseases

Année:

2012

Langue:

english

Fichier:

PDF, 1.40 MB

english, 2012

9

The absence of functional PI3Kγ prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice

Willemijn A. van Dop, Stefano Marengo, Anje A. te Velde, Elisa Ciraolo, Irene Franco, Fiebo J. ten Kate, Guy E. Boeckxstaens, James C. Hardwick, Daan W. Hommes, Emilio Hirsch, Gijs R. van den Brink

Journal:

Immunology Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2010

10

Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils

Hidekazu Suzuki, Yuriko Minegishi, Yohei Nomoto, Takayuki Ota, Tatsuhiro Masaoka, Gijs R van den Brink, Toshifumi Hibi

Journal:

The Journal of Pathology

Année:

2005

Langue:

english

Fichier:

PDF, 940 KB

english, 2005

11

From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease

BERNT VAN DEN BLINK, TESSA ten HOVE, GIJS R. VAN DEN BRINK, MAIKEL P. PEPPELENBOSCH, SANDER J.H. VAN DEVENTER

Journal:

Annals of the New York Academy of Sciences

Année:

2002

Fichier:

PDF, 902 KB

2002

12

Hh pathway expression in human gut tissues and in inflammatory gut diseases

Nielsen, Corinne M, Williams, Jerrell, van den Brink, Gijs R, Lauwers, Gregory Y, Roberts, Drucilla J

Journal:

Laboratory Investigation

Année:

2004

Langue:

english

Fichier:

PDF, 1.13 MB

english, 2004

13

Linking pathways in colorectal cancer

van den Brink, Gijs R

Journal:

Nature Genetics

Année:

2004

Langue:

english

Fichier:

PDF, 97 KB

english, 2004

14

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

van den Brink, Gijs R, Bleuming, Sylvia A, Hardwick, James C H, Schepman, Berber L, Offerhaus, G Johan, Keller, Josbert J, Nielsen, Corinne, Gaffield, William, van Deventer, Sander J H, Roberts, Druci

Journal:

Nature Genetics

Année:

2004

Langue:

english

Fichier:

PDF, 2.74 MB

english, 2004

15

Bone morphogenetic protein signalling in colorectal cancer

Hardwick, James C., Kodach, Liudmila L., Offerhaus, G. Johan, van den Brink, Gijs R.

Journal:

Nature Reviews Cancer

Année:

2008

Langue:

english

Fichier:

PDF, 510 KB

english, 2008

16

NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps

Hardwick, James CH, van den Brink, Gijs R, Offerhaus, G J, van Deventer, Sander JH, Peppelenbosch, Maikel P

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 1.92 MB

english, 2001

17

The Morphogenetic Code and Colon Cancer Development

Gijs R. van den Brink, G. Johan Offerhaus

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2007

18

Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression

Mark Löwenberg, Auke P. Verhaar, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Trends in Molecular Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 462 KB

english, 2007

19

Conscious sedation for EUS of the esophagus and stomach: A double-blind, randomized, controlled trial comparing midazolam with placebo

Peter I. Bonta, Maarten F. Kok, Jacques J.G.H.M. Bergman, Gijs R. Van den Brink, Jorrit S. Lemkes, Guido N.J. Tytgat, Paul Fockens

Journal:

Gastrointestinal Endoscopy

Année:

2003

Langue:

english

Fichier:

PDF, 86 KB

english, 2003

20

Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn’s disease

Jan M.H Van den Brande, Henri Braat, Gijs R van den Brink, Henri H Versteeg, Christiaan A Bauer, Inge Hoedemaeker, Catherine van Montfrans, Daan W Hommes, Maikel P Peppelenbosch, Sander J.H van Devent

Journal:

Gastroenterology

Année:

2003

Langue:

english

Fichier:

PDF, 322 KB

english, 2003

21

Expression of sonic hedgehog in the human and mouse stomach, a possible as a gastric epithelial morphostal

Gijs R. Van Den Brink, James C.H. Hardwick, Guido N.J. Tytgat, Menno A. Brink, Fiebo J. Ten Kate, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Année:

2001

Langue:

english

Fichier:

PDF, 189 KB

english, 2001

22

351 Lovastatin Acts As Demethylating Agent in Colorectal Cancer Cell Lines

Liudmila L. Kodach, Rutger Jacobs, Maikel P. Peppelenbosch, Daniel Hommes, Gijs R. van den Brink, James C. Hardwick

Journal:

Gastroenterology

Année:

2009

Langue:

english

Fichier:

PDF, 121 KB

english, 2009

23

1093 The Absence of Functional PI3Kγ Has a Protective Effect On DSS-Induced Colitis in Mice

Willemijn A. van Dop, Stefano Marengo, Anje A. Te Velde, Fiebo J. ten Kate, Daniel Hommes, Guy E. Boeckxstaens, Emilio Hirsch, Gijs R. van den Brink

Journal:

Gastroenterology

Année:

2009

Langue:

english

Fichier:

PDF, 74 KB

english, 2009

24

87 Conditional Loss of Intestinal Hedgehog Signaling Results in a Regenerative Response and Subsequently in Loss of Villi and the Spontaneous Development of Chronic Enteritis

Willemijn A. van Dop, Elisabeth A. Wassenberg, Beate Lanske, Alan R. Clarke, Johan Offerhaus, Daniel W. Hommes, James C. Hardwick, Izak Biemond, Gijs R. van den Brink

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 53 KB

english, 2010

25

186 Constitutive Hedgehog Signaling Impairs Maturation and Migration of Esophageal Epithelial Precursor Cells

Willemijn A. van Dop, Anja Uhmann, Viljar Jaks, Johan Offerhaus, Marius A. van den Bergh Weerman, Jarom Heijmans, Daniel W. Hommes, James C. Hardwick, Rune Toftgård, Heidi Hahn, Gijs R. van den Brink

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 46 KB

english, 2010

26

1019 ATG16L1 and IRGM Contribute to the Regulation of Immune Responses

Manon E. Wildenberg, Anne Christine W. Vos, Marjolijn Duijvestein, Auke Verhaar, Caterina Strisciuglio, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 50 KB

english, 2010

27

Statins Reduce the Risk on Colorectal Cancer in Relation to SMAD4 Expression

Rutger J. Jacobs, Liudmila L. Kodach, Nikki L. Weil, Philip W. Voorneveld, Mariel Casparie, Ron M. Herings, Hans Morreau, Gijs R. van den Brink, Daniel W. Hommes, James C. Hardwick

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 47 KB

english, 2011

28

Autophagy Regulates Immune Responses Through Destabilization of the Immunological Synapse

Manon E. Wildenberg, Anne Christine W. Vos, Simone C. Wolfkamp, Marjolijn Duijvestein, Auke Verhaar, Anje A. Te Velde, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 175 KB

english, 2011

29

407 Rock-Inhibitors Reduce the Induction of Epithelial to Mesenchymal Transition, Migration and Invasion Caused by Bone Morphogentic Protein Signaling in SMAD4 Deficient Colorectal Cancers

Philip Voorneveld, Liudmila L. Kodach, Rutger J. Jacobs, Gijs R. van den Brink, Daniel W. Hommes, Maikel P. Peppelenbosch, James C. Hardwick

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 65 KB

english, 2012

30

646 Statins Inhibit the PI3K/AKT/mTOR Pathway in Colorectal Cancer Through Upregulation of PTEN in a BMP Dependent Manner

Rutger J. Jacobs, Liudmila L. Kodach, Philip Voorneveld, Jarom Heijmans, Sander H. Diks, Gijs R. van den Brink, Daniel W Hommes, Maikel P. Peppelenbosch, James C. Hardwick

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 66 KB

english, 2012

31

Leptin Is a Growth Factor for Colonic Epithelial Cells

James C.H. Hardwick, Gijs R. Van Den Brink, G.J. Offerhaus, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Année:

2001

Langue:

english

Fichier:

PDF, 968 KB

english, 2001

32

Sonic Hedgehog Regulates Gastric Gland Morphogenesis in Man and Mouse

Gijs R. Van den Brink, James C.H. Hardwick, Guido N.J. Tytgat, Menno A. Brink, Fiebo J. Ten Kate, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Année:

2001

Langue:

english

Fichier:

PDF, 1019 KB

english, 2001

33

Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon

James C.H. Hardwick, Gijs R. Van Den Brink, Sylvia A. Bleuming, Isabel Ballester, Jan.M.H. Van Den Brande, Josbert J. Keller, G.Johan A. Offerhaus, Sander J.H. Van Deventer, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Année:

2004

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2004

34

Expression of Hedgehog Pathway Components in the Adult Colon

Gijs R. Van Den Brink, Maikel P. Peppelenbosch

Journal:

Gastroenterology

Année:

2006

Langue:

english

Fichier:

PDF, 61 KB

english, 2006

35

The Effect of Statins in Colorectal Cancer Is Mediated Through the Bone Morphogenetic Protein Pathway

Liudmila L. Kodach, Sylvia A. Bleuming, Maikel P. Peppelenbosch, Daniel W. Hommes, Gijs R. van den Brink, James C.H. Hardwick

Journal:

Gastroenterology

Année:

2007

Langue:

english

Fichier:

PDF, 2.73 MB

english, 2007

36

The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers

Liudmila L. Kodach, Eliza Wiercinska, Noel F.C.C. de Miranda, Sylvia A. Bleuming, Alex R. Musler, Maikel P. Peppelenbosch, Evelien Dekker, Gijs R. van den Brink, Carel J.M. van Noesel, Hans Morreau, D

Journal:

Gastroenterology

Année:

2008

Langue:

english

Fichier:

PDF, 4.62 MB

english, 2008

37

Sonic Hedgehog: A Link Between Inflammation, Gastric Atrophy, and Acid Suppression?

Willemijn A. Van Dop, Gijs R. Van Den Brink

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 428 KB

english, 2010

38

Anti–Tumor Necrosis Factor-α Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner

Anne Christine W. Vos, Manon E. Wildenberg, Marjolijn Duijvestein, Auke P. Verhaar, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Année:

2011

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2011

39

Morphogens and the Parietal Cell: Shaping Up Acid Secretion

Jarom Heijmans, Gijs R. van den Brink

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 960 KB

english, 2010

40

Autophagy Attenuates the Adaptive Immune Response by Destabilizing the Immunologic Synapse

Manon E. Wildenberg, Anne Christine W. Vos, Simone C.S. Wolfkamp, Marjolijn Duijvestein, Auke P. Verhaar, Anje A. Te Velde, Gijs R. van den Brink, Daniel W. Hommes

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 3.76 MB

english, 2012

41

Foxf2: A Mesenchymal Regulator of Intestinal Adenoma Development

van den Brink, Gijs R., Rubin, Deborah C.

Journal:

Gastroenterology

Année:

2013

Langue:

english

Fichier:

PDF, 667 KB

english, 2013

42

Vitamin D deficiency in Crohn's disease and healthy controls: A prospective case–control study in the Netherlands

de Bruyn, Jessica R., van Heeckeren, Rosanne, Ponsioen, Cyriel Y., van den Brink, Gijs R., Löwenberg, Mark, Bredenoord, Albert J., Frijstein, Gerard, D’Haens, Geert R.

Journal:

Journal of Crohn's and Colitis

Année:

2014

Langue:

english

Fichier:

PDF, 336 KB

english, 2014

43

M1189 Statin Treatment of Colon Cancer Cells Leads to an Overall Downregulation of Receptor Tyrosine Kinase Activity

Jacobs, Rutger J., Kodach, Liudmila L., Diks, Sander H., Heijmans, Jarom, Hommes, Daniel W., van den Brink, Gijs R., Peppelenbosch, Maikel P., Hardwick, James C.

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 51 KB

english, 2010

44

Tu1679 Vitamin D Potentiates the Immunosuppressive Effect of Anti-TNF Induced Regulatory Macrophages

Levin, Alon D., Wildenberg, Manon, Vos, Anne Christine, de Bruyn, Jessica R., Brandse, Johannan F., D'Haens, Geert R., van den Brink, Gijs R.

Journal:

Gastroenterology

Année:

2013

Langue:

english

Fichier:

PDF, 58 KB

english, 2013

45

W1806 Anti-TNF Induced Inhibition of T Cell Proliferation in a Mixed Lymphocyte Reaction is FC Receptor Dependent

Vos, Anne Christine W., Wildenberg, Manon E., Duijvestein, Marjolijn, Verhaar, Auke, Heijmans, Jarom, van den Brink, Gijs R., Hommes, Daniel W.

Journal:

Gastroenterology

Année:

2010

Langue:

english

Fichier:

PDF, 67 KB

english, 2010

46

Mo1693 FcR-Mediated Effector Function Contributes to the Therapeutic Response of Anti-TNF Monoclonal Antibodies in a Mouse Model of IBD

Levin, Alon D., Wildenberg, Manon E., D'Haens, Geert R., van den Brink, Gijs R.

Journal:

Gastroenterology

Année:

2014

Langue:

english

Fichier:

PDF, 305 KB

english, 2014

47

212 Serum CRP Is a Better Early Marker for Response to Infliximab Induction Therapy Than Fecal Calprotectin in Patients With Moderate to Severe Ulcerative Colitis

Brandse, Johannan F., Jansen, Jeroen M., Baars, Paul A., Lowenberg, M., Ponsioen, Cyriel, van den Brink, Gijs R., D'Haens, Geert R.

Journal:

Gastroenterology

Année:

2014

Langue:

english

Fichier:

PDF, 496 KB

english, 2014

48

Sa1207 Leukocyte Scintigraphy As a Tool to Measure Inflammatory Load in Ulcerative Colitis

Brandse, Johannan F., Bennink, Roelof J., Van Eeden, Susanne, Baars, Paul A., Lowenberg, M., Ponsioen, Cyriel, van den Brink, Gijs R., D'Haens, Geert R.

Journal:

Gastroenterology

Année:

2014

Langue:

english

Fichier:

PDF, 133 KB

english, 2014

49

Tu1971 Anti-TNF Induced Regulatory Macrophages Display High Levels of Autophagy

Vos, Anne Christine, Wildenberg, Manon, Levin, Alon D., van den Brink, Gijs R., Hommes, Daniel W.

Journal:

Gastroenterology

Année:

2012

Langue:

english

Fichier:

PDF, 64 KB

english, 2012

50

Su1209 Reduced Length of Hospitalisation and Treatment Costs With Infliximab Versus Ciclosporin in Patients With Severe Ulcerative Colitis

Lowenberg, M., Duijvis, Nicolette W., Ponsioen, Cyriel, van den Brink, Gijs R., Bemelman, Willem A., Fockens, Paul, D'Haens, Geert R.

Journal:

Gastroenterology

Année:

2013

Langue:

english

Fichier:

PDF, 166 KB

english, 2013